10 Best Supplements For Weight Gain And Muscle Gain in 2026

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Our best overall supplement for weight and muscle gain is Dymatize Super Mass Gainer, for its high-calorie formula that combines fast- and slow-digesting proteins with creatine. For a massive calorie punch, consider the Best High-Calorie pick, Optimum Nutrition Serious Mass, or the Best Clean Formula, NAKED Mass.

These picks help when eating enough food is a daily challenge. Many people struggle to consume the sheer volume of calories and protein needed to support muscle growth, especially with a fast metabolism or high activity level. We built this guide by researching product specifications, manufacturer data, expert insights, and patterns in owner feedback to help you find a practical solution.

Top 10 Supplements For Weight Gain And Muscle Gain in the Market

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The Best Supplements For Weight Gain And Muscle Gain, Reviewed

#1Best Overall

Dymatize Super Mass Gainer Protein Powder

Dymatize Super Mass Gainer Protein Powder
Calories per serving1,280
Protein per serving52g
Protein blendWhey + casein
Creatine per serving1g
Servings per container8
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What We Like

  • High-calorie formula supports aggressive mass goals
  • Combines fast- and slow-digesting proteins for sustained delivery
  • Includes creatine and 14 vitamins/minerals for recovery support
  • Versatile for blending into various calorie-dense recipes

Trade-offs

  • 245g of carbs per serving is substantial
  • Large single-serving volume may be difficult to consume

With 1,280 calories and 52 grams of protein per serving, this gainer is built for a single, demanding purpose: adding serious mass. It pairs a hefty dose of fast-digesting whey with slow-release casein, aiming to fuel muscles immediately and then over several hours. The addition of a gram of creatine and a vitamin and mineral blend rounds out a formula designed for the individual whose primary barrier to growth is simply getting enough calories and nutrients in. It’s a straightforward, calorie-dense engine for weight gain.

The trade-off is in the serving size and count. That massive calorie load comes with 245 grams of carbohydrates, which can be a lot to handle in one sitting. For someone who needs a slightly less carb-forward option or more servings per tub, the Optimum Nutrition Pro Gainer provides a different macro profile and a larger total package.

Best for: Athletes and bodybuilders in a hard-gaining phase who struggle to meet extreme daily caloric needs through food alone. Not ideal for those seeking a lean, low-carb bulk or a high-serving-count value.

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#2Best High-Calorie

Optimum Nutrition Serious Mass Protein Powder

Optimum Nutrition Serious Mass Protein Powder
Calories per serving1,250
Protein per serving50 grams
Carbohydrates per servingOver 250 grams
Essential vitamins & minerals20+
Container size6 pounds
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What We Like

  • Massive 1,250-calorie serving for bulking
  • 50g protein blend aids muscle recovery
  • High carbohydrate content fuels sustained energy
  • Includes 20+ vitamins for nutritional balance

Trade-offs

  • Serving size may be excessive for casual users

A single serving delivers 1,250 calories, which is a definitive tool for anyone struggling to hit a substantial daily calorie surplus through food alone. This product suits individuals in a dedicated bulking phase who need a dense, all-in-one shake to consistently support weight and muscle gain, backed by a 50-gram protein hit and a full spectrum of vitamins.

Each two-scoop serving delivers over 1,200 calories, which is designed for dedicated bulking phases when regular meals alone cannot meet extreme energy needs. This makes it overkill for someone just seeking a post-workout protein bump. Among Optimum Nutrition’s own line, the Pro Gainer offers 60 grams of protein per serving, but Serious Mass focuses on maximum caloric intake for its specific purpose.

Best for: Athletes and lifters in an aggressive mass-gaining phase who need a high-calorie foundation. Not ideal for those seeking a lean protein supplement or with modest calorie goals.
#3Best Clean Formula

NAKED Mass Natural Weight Gainer Powder

NAKED Mass Natural Weight Gainer Powder
Calories per serving1,250
Protein per serving50g
Carbohydrates per serving252g
Sugar per serving5g
Key ingredientsWhey, casein, organic tapioca maltodextrin
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What We Like

  • Extremely clean, three-ingredient formula
  • NSF Certified for purity and safety
  • Combines fast and slow-digesting proteins
  • Uses organic, gluten-free complex carbohydrates

Trade-offs

  • Massive 1,250-calorie serving requires significant consumption discipline
  • Unflavored formula demands preparation creativity for palatability
  • Large 8-pound container has a substantial storage footprint

With only three ingredients and no artificial additives, NAKED Mass offers a straightforward option for buyers focused on label transparency. Each 1,250-calorie serving delivers protein from whey and casein alongside organic tapioca maltodextrin, providing a known ingredient list. This formulation is intended for those who prefer a simple, unflavored base to which they can add their own flavors and ingredients.

Such a clean, high-calorie load comes in an unflavored form, so you’ll be responsible for making it taste good. Compared to a product like Optimum Nutrition Serious Mass, which arrives ready-mixed with flavors and additional supplements like creatine, NAKED Mass provides a blank, premium canvas. You gain purity but lose convenience, making it a specialist tool rather than an all-in-one solution.

Best for: The label-scrutinizing hard gainer committed to a whole-food-adjacent bulking protocol. Not ideal for someone seeking a flavored, ready-to-mix shake with added performance supplements.

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#4Best High-Protein Blend

Mutant Mass Extreme Gainer Protein Powder

Mutant Mass Extreme Gainer Protein Powder
Calories per serving1,100
Protein per serving56 g
Protein blendWhey isolate, concentrate & casein
BCAAs per serving12.2 g
Servings per pouch16
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What We Like

  • High-protein blend for sustained muscle support
  • Includes whole-food ingredients like oats and sweet potato
  • Provides comprehensive EAA and BCAA profile
  • Concentrated calorie source for weight gain

Trade-offs

  • Serving size is substantial at 1,100 calories
  • Pouch weighs 2.2 pounds

At 56 grams of protein from a blend of whey and casein, this gainer is built for sustained muscle support throughout the day, not just a post-workout spike. It suits someone struggling to hit a high daily calorie and protein target through whole foods alone, offering a dense, convenient solution. The inclusion of whole-food ingredients like rolled oats and sweet potato is a thoughtful touch for a product in this category.

Mutant Mass Extreme Gainer provides 1,100 calories per serving, a substantial energy intake for weight gain goals. Its formula includes a blend of whey isolate, whey concentrate, and casein to supply 56 grams of protein. The product also incorporates whole-food ingredients like barley, sweet potato, and rolled oats.

Best for: The lifter needing a high-protein, high-calorie blend with whole-food ingredients to support a structured mass-building diet. Not ideal for someone seeking a light, single-serve supplement or a minimal-ingredient formula.

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#5Best With Creatine

MuscleTech High Protein Mass Gainer

MuscleTech High Protein Mass Gainer
Protein per serving60g
Calories per serving1,500
Carbohydrates per serving304g
Scoops per tub42
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What We Like

  • Extremely high 1,500-calorie serving for mass
  • Includes proven HPLC-tested creatine monohydrate
  • Delivers 60g of protein per shake

Trade-offs

  • Requires a 6-scoop serving, which is large
  • 304g of carbs per serving demands significant digestion

The decisive fact here is the 1,500-calorie serving when mixed with milk, a caloric load designed for one thing: pushing through a hard-gainer plateau. It suits someone whose primary obstacle is simply eating enough, and it bundles in a clinically backed dose of creatine monohydrate to support the strength gains needed to put those calories to work. This is for the individual tracking macros and workouts meticulously but still struggling to move the scale, where convenience and density trump everything else.

Each six-scoop serving delivers 304 grams of carbohydrates, a substantial amount that requires a significant digestive commitment. When mixed with skim milk, it provides 1,500 calories and 60 grams of protein, making it a high-volume option for those prioritizing maximum calorie intake per shake. The formula includes HPLC-tested creatine monohydrate and branched-chain amino acids, positioning it as an engineered, all-in-one nutritional supplement.

Best for: The dedicated hard-gainer who needs maximum caloric and creatine support in a single, efficient shake. Not ideal for those seeking a lean gain, a simple ingredient list, or a modest serving size.

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#6Best High-Protein Option

Optimum Nutrition Pro Gainer Protein Powder

Optimum Nutrition Pro Gainer Protein Powder
Calories per serving650
Protein per serving60g
Carbohydrates per servingMore than 80g
Sugar per servingLess than 8g
Package weight10.2 pounds
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What We Like

  • High 60g protein blend per serving
  • Substantial 650-calorie serving for gains
  • High carbohydrate content aids energy restoration
  • Relatively low sugar for a mass gainer

Trade-offs

  • 10.2-pound bulk is cumbersome for travel
  • 650 calories per serving is a significant commitment
  • Large 17-inch tall container requires ample storage

A 60-gram protein hit per serving makes this a serious tool for muscle repair and growth, squarely aimed at those whose primary goal is packing on lean mass. The 650-calorie foundation provides the necessary surplus for weight gain, while the carbohydrate load helps refuel depleted glycogen stores. It suits someone with a demanding training regimen who needs a dense, protein-forward nutritional anchor.

You must consider the sheer volume you’re committing to, both in the 10.2-pound container and in each substantial serving. If your aim is sheer caloric density above all else, the Dymatize Super Mass Gainer offers over double the calories per serving. This Optimum Nutrition option, however, prioritizes a cleaner protein-to-calorie ratio for those focusing on muscle quality alongside size.

Best for: Athletes prioritizing high protein intake for lean muscle gain within a controlled calorie surplus. Not ideal for those seeking extreme caloric density or needing a highly portable supplement.
#7Best High-Fiber

BSN True-Mass Weight Gainer Protein Powder

BSN True-Mass Weight Gainer Protein Powder
Calories per serving1200
Protein per serving50g
Carb-to-protein ratio4:1
Fiber per serving10g
Package weight10.2 Pounds
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What We Like

  • Extremely high 1200-calorie serving for mass
  • Contains a substantial 10g of fiber per serving
  • Multi-source protein matrix with 50g protein
  • Includes branched chain and essential amino acids

Trade-offs

  • Large 10.2-pound container requires significant storage space
  • High 4:1 carb-to-protein ratio may not suit lean-gain goals
  • The 1200-calorie serving size demands a substantial appetite

With 1200 calories per serving, this is BSN’s most calorie-dense mass gainer, built for pushing past plateaus when whole food intake simply can’t keep up. The 10 grams of fiber per serving is its standout feature, a practical inclusion that can help manage the digestive load of such a high-calorie regimen. This product suits someone in an extreme training phase who needs maximum caloric fuel and appreciates the digestive support that fiber provides.

BSN True-Mass prioritizes high-calorie volume with a 4:1 carbohydrate-to-protein ratio, a formula designed for significant mass addition rather than lean-focused gains. Its 10 grams of fiber per serving is a notable inclusion for digestive support, which can be a concern with such a calorie-dense product. This combination makes it a specific tool for hard-gainers whose primary goal is increasing overall body weight.

Best for: The hard-training individual needing maximum calories and digestive support from fiber. Not ideal for those seeking a lean, high-protein macro profile.
#8Best Low-Fat

NutraBio Extreme Mass Gainer Protein Powder

NutraBio Extreme Mass Gainer Protein Powder
Protein per serving53g
Carbs per serving99g
Fat per serving6g
Key protein blendWPC80 & Micellar Casein
CertificationsGluten-free, soy-free, kosher, halal
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What We Like

  • Low-fat profile of only 6g per serving
  • High 53g protein content for muscle support
  • Fully transparent label with no proprietary blends
  • Third-party tested for purity and potency

Trade-offs

  • 99g of carbs per serving may be excessive for some diets

With only 6 grams of fat per serving, this mass gainer stands out for anyone prioritizing lean gains and a cleaner macronutrient split. It delivers a hefty 53 grams of protein from a straightforward whey and casein blend, which supports sustained muscle recovery. The formula is packed with complex carbs and fiber to fuel hard training. Its fully disclosed ingredients list and third-party testing also offer a level of transparency that appeals to skeptical buyers who read labels.

You should be prepared for the sheer volume of the shake, which at 99 grams of carbs can feel like a meal replacement. This makes it a dedicated tool for a hardgainer’s calorie surplus, not a casual snack. Compared to something like the Dymatize Super Mass Gainer, which packs more calories and carbs into a denser formula, the NutraBio option is the disciplined choice for those who want the mass without the extra fat.

Best for: Athletes and bodybuilders seeking a high-protein, low-fat mass gainer with fully transparent sourcing. Not ideal for those with a lower calorie tolerance or who prefer minimal, single-scoop servings.
#9Best Moderate-Calorie

Muscle Milk Gainer Protein Powder

Muscle Milk Gainer Protein Powder
Serving size4 scoops (162g)
Calories per serving650
Protein per serving32g
Leucine per serving3g
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What We Like

  • Moderate 650-calorie serving for steady gains
  • 32g protein blend for muscle support
  • Versatile pre/post-workout or meal replacement use
  • Includes 3g leucine from milk proteins

Trade-offs

  • Requires 4 large scoops per serving
  • Shaker bottle is a separate purchase

With 650 calories in the recommended four-scoop serving, this gainer provides a substantial energy surplus for adding mass, yet avoids the extreme bulk of some high-calorie shakes. Its 32 grams of protein, including 3 grams of leucine from milk proteins, supports muscle repair. This positions it as a straightforward option for supplementing a diet rather than replacing whole meals, fitting between standard protein powders and heavier-duty mass builders.

Be aware of the serving size and count. Each shake requires four scoops, which depletes the five-pound container in about two weeks of daily use. Compared to a product like Optimum Nutrition Serious Mass, which packs over twice the calories per serving, this is a more moderate approach to weight gain. It’s for incremental progress, not a caloric bulldozer.

Best for: Athletes seeking a moderate-calorie boost to support a consistent muscle-building diet. Not ideal for individuals requiring extreme caloric intake due to a fast metabolism or very high activity levels.
#10Best Ready-to-Drink

BOOST Very High Calorie Nutritional Drink

BOOST Very High Calorie Nutritional Drink
Calories per serving530
Protein per serving22 g
Key nutrients26 vitamins & minerals
Serving size8 fl oz
Packaging24-pack
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What We Like

  • Provides 530 nutrient-dense calories per drink
  • Includes 22g of high-quality protein for muscle maintenance
  • Convenient, ready-to-drink format, no mixing required
  • Fortified with key vitamins and minerals for overall health

Trade-offs

  • At 8 fl oz, the volume is small compared to typical powder servings
  • Drink's thickness may require drinking over ice for some

The 530 calories and 22 grams of protein in each 8-ounce bottle make BOOST a uniquely convenient tool for consistent calorie intake. You don’t need a blender or a shaker bottle; you just need a fridge and a few seconds. This is the pick for someone whose primary barrier to weight gain is simply the effort and time of preparing large, calorie-dense shakes multiple times a day. It suits a routine where grabbing a chilled drink post-workout or between meetings is the only reliable way to hit a surplus.

This drink provides 530 calories in a ready-to-consume 8-ounce bottle, which simplifies weight gain by eliminating any mixing or preparation. While convenient, its caloric content is lower per serving than many dedicated mass gainer powders, so reaching the highest calorie targets would require consuming multiple bottles. It represents a premium convenience for those prioritizing ease over maximum caloric density per purchase.

Best for: Individuals who need a no-prep, portable solution for consistent supplemental calories and protein to support weight gain. Not ideal for those seeking the highest possible calorie intake per serving or the most cost-effective bulk-calorie source.

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How We Evaluated Weight Gain And Muscle Gain Supplements

Our evaluation focused on comparing product specifications and formulas against the primary goals of this category: delivering concentrated calories and protein to support a caloric surplus. We prioritized calorie content per serving, protein source and quantity, and the inclusion of performance-supporting ingredients like creatine or digestive enzymes, as these are the key levers for mass gain.

We also considered the practical realities of consumption, like serving size volume and mixability, which directly impact long-term adherence. Our research-based approach, which synthesizes manufacturer data and owner experiences, cannot replicate the results of controlled clinical trials or predict an individual’s specific metabolic response.

What To Look For In Supplements For Weight Gain And Muscle Gain

Choosing the right supplement depends on your specific calorie needs, dietary preferences, and tolerance for large serving sizes. The goal is to find an efficient tool that complements your diet without causing digestive distress or replacing whole foods you should be eating.

Look for a formula that matches your daily calorie gap, provides high-quality protein (20-60g per serving), and includes performance aids like creatine if your training intensity demands it. Consider mixability and flavor if you plan to use it daily.

Caloric Density

The core function of a mass gainer is to deliver concentrated calories. Servings range from 650 to over 1,500 calories. Your choice should be based on your calculated daily surplus needs; an excessively high dose can lead to unwanted fat gain if it surpasses your requirements. Formulas often use carbohydrate blends of maltodextrin, oats, or waxy maize to achieve this density, which also impacts the speed of digestion and energy delivery.

Protein Quality & Quantity

Adequate protein is non-negotiable for muscle repair and growth. Per serving protein content in these products ranges from about 30g to 60g. Look for complete protein sources like whey (fast-digesting) or casein (slow-digesting), or a blend of both for sustained amino acid delivery. The inclusion of essential amino acids (EAAs) or branched-chain amino acids (BCAAs) can be beneficial, but they are not a substitute for sufficient total protein intake from protein supplements.

Supporting Ingredients

Ingredients beyond calories and protein can influence results and digestibility. Creatine monohydrate is a well-researched supplement shown to support strength and lean mass gains when combined with training. Some formulas include digestive enzymes to help manage the large nutrient load, or fiber to promote satiety and gut health. Be wary of proprietary blends that obscure exact dosages of these evidence-backed supplements.

  • Calculate your maintenance calories and add 300-500 for a lean surplus before choosing a serving size.
  • If you’re sensitive to lactose or artificial sweeteners, scrutinize the ingredient list for alternatives.
  • For a “cleaner” profile, look for certifications like NSF Certified for Sport or Informed Choice.
  • Consider mixability: clumpy shakes are difficult to finish, which defeats the purpose.
  • Factor in cost per serving, as high-calorie options can be consumed quickly.

The most effective supplement is the one you can consistently consume and digest comfortably.

Supplements For Weight Gain And Muscle Gain Compared

For a quick overview of how our top picks stack up, the table below compares key specifications like calories, protein, and primary ingredients.

ProductCalories per servingProtein per servingContainer weight
Dymatize Super Mass Gainer Protein Powder1,28052g1.3 pounds
Optimum Nutrition Serious Mass Protein Powder1,25050 grams6.0 pounds
NAKED Mass Natural Weight Gainer Powder1,25050g8.0 pounds
Mutant Mass Extreme Gainer Protein Powder1,10056 g2.2 Pounds
MuscleTech High Protein Mass Gainer1,50060g5.2 Pounds
Optimum Nutrition Pro Gainer Protein Powder65060g10.2 pounds
BSN True-Mass Weight Gainer Protein Powder120050g10.2 Pounds
NutraBio Extreme Mass Gainer Protein PowderN/A53g7.1 Pounds
Muscle Milk Gainer Protein Powder65032g5.0 Pounds
BOOST Very High Calorie Nutritional Drink53022 g12.0 Pounds

Frequently Asked Questions

What is the best supplement for both muscle growth and weight gain?

A high-quality mass gainer is often the most practical choice, as it addresses both needs by providing a significant caloric surplus alongside ample protein. Our top pick, Dymatize Super Mass Gainer, exemplifies this by combining over 1,200 calories with a protein blend and creatine, making it one of the best options for hard-training individuals.

Which supplement is best for muscle gain and weight loss?

These are opposing goals. Supplements for muscle gain require a caloric surplus, while weight loss requires a deficit. For body recomposition (losing fat while gaining muscle), the focus shifts to high-protein, lower-calorie supplements like whey or casein protein isolates, consumed within a carefully managed diet to support muscle growth without excess calories.

Can I still build muscle on metformin?

Metformin may slightly blunt muscle protein synthesis, but building muscle is still possible with strategic nutrition. Ensuring a sufficient caloric surplus and a high protein intake (1.6-2.2g per kg of body weight) becomes even more critical. Consulting a doctor about integrating supplements like protein powders is advisable.

What are the big 3 supplements?

In the context of muscle building, the “big three” foundational supplements are often considered to be a high-quality protein powder, creatine monohydrate, and a well-formulated multivitamin. These cover the basic needs for muscle repair, performance, and overall nutritional support, forming the core of many effective protocols.

Are mass gainers good for skinny guys?

Mass gainers are designed for people who struggle to eat enough to gain weight, often called “hard gainers.” They offer a convenient, calorie-dense way to create the necessary surplus. Still, you should view them as a supplement to a solid diet, not a replacement. Choose from the top supplements that fit your tolerance and goals.

The Bottom Line

For the athlete or dedicated lifter needing comprehensive support for aggressive mass goals, Dymatize Super Mass Gainer is our best overall pick due to its high-calorie formula, protein blend, and included creatine. If your budget is a primary concern or you need a ready-to-drink option, look to our Best Moderate-Calorie or Best Ready-to-Drink picks, Muscle Milk Gainer and BOOST Very High Calorie Nutritional Drink, respectively. Ultimately, the single most important factor is matching the supplement’s caloric and protein density to your personal daily requirements and digestive tolerance for consistent, sustainable gains.