10 Best Supplements To Take For Muscle Growth in 2026

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Our research-based top pick for a muscle growth supplement is Optimum Nutrition Creatine Monohydrate Powder, a no-frills, high-purity creatine that’s well-supported by science. We also highlight Optimum Nutrition Gold Standard Whey Protein as a premium protein and Dymatize ISO100 for a fast-absorbing option. Muscle building depends on more than lifting; it requires strategic nutrition to fuel muscle protein synthesis and recovery. We sifted through manufacturer data, expert round-ups, and patterns in owner feedback to find these 10 picks, giving you a clear comparison of trusted options.

Top 10 Supplements For Muscle Growth in the Market

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The Best Supplements For Muscle Growth, Reviewed

#1Best Overall

Optimum Nutrition Creatine Monohydrate Powder

Optimum Nutrition Creatine Monohydrate Powder
Serving Size5g
FormMicronized Monohydrate Powder
Servings Per Container120
Third-Party TestingBanned Substance Tested
Brand StatureWorld's #1 Sports Nutrition Brand
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What We Like

  • 5g of pure creatine monohydrate per serving
  • Micronized for easy mixing in shakes
  • Banned substance tested for safety
  • Supports muscle strength, power, and recovery

Trade-offs

  • Unflavored powder requires mixing with another beverage
  • No additional ingredients for taste or enhanced absorption

Each serving delivers 5g of micronized creatine monohydrate, which is the clinically studied dose for increasing intramuscular phosphocreatine stores to fuel high-intensity exercise and support muscle growth over time. This makes it a straightforward, effective choice for anyone focused on measurable strength gains and improved training capacity, backed by the manufacturing consistency of a major brand. The lack of flavoring or other additives keeps the formula simple and predictable, which suits a skeptical tinkerer who wants to isolate the effects of a single, well-researched compound.

Optimum Nutrition Creatine Monohydrate Powder delivers 5 grams of pure micronized creatine monohydrate per serving, which allows you to control your exact intake without additional ingredients. Unlike blended supplements like MuscleTech Nitro-Tech Whey Protein Powder that combine creatine with protein and BCAAs, this product contains only creatine. This single-ingredient focus suits users who prefer to build their own supplement stack from separate components.

Best for: Lifters seeking a no-frills, high-purity creatine monohydrate supplement from an established brand. Not ideal for those who want a pre-flavored, all-in-one muscle-building shake.
#2Best Premium Protein

Optimum Nutrition Gold Standard Whey Protein

Optimum Nutrition Gold Standard Whey Protein
Protein per serving24g
BCAAs per serving5.5g
EAA per serving11g
Banned substance testedYes
Container size2.0 pounds
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What We Like

  • Blend of whey isolate and concentrate
  • Includes essential and branched-chain amino acids
  • Banned substance tested for safety
  • Instantized formula for easy mixing

Trade-offs

  • 24g protein per scoop, less than some isolates
  • 2-pound size offers fewer total servings than larger tubs

The 24 grams of protein per scoop comes from a blend of whey protein isolate and concentrate, a formula designed to provide a balance of fast absorption and sustained release. This makes it a versatile, anytime protein, not just a post-workout shake, which suits someone looking for a single, reliable protein source throughout their day. It’s backed by a brand with a long history in sports nutrition and is banned substance tested, which adds a layer of confidence if you’re cautious about what goes into your body.

Optimum Nutrition Gold Standard Whey offers 24 grams of protein per scoop from a blend of isolate and concentrate. This provides a balanced formula for muscle support after a workout or as a between-meal snack. Its two-pound container is more compact than many four-pound competitors, which means it takes up less space in a pantry but holds fewer total servings. While some pure isolates like Dymatize ISO100 list a higher protein count per serving, this product focuses on a mix that includes 5.5 grams of BCAAs for recovery and is designed for easy mixing with just a shake.

Best for: Athletes seeking a versatile, trusted protein from a long-established brand, suitable for any time of day. Not ideal for those looking for the largest container size or the highest protein-per-scoofigure from an isolate.
#3Best Fast-Absorbing Protein

Dymatize ISO100 Whey Isolate Protein Powder

Dymatize ISO100 Whey Isolate Protein Powder
Protein per serving25g
Protein typeHydrolyzed whey isolate
Fat per serving1g
Servings per container20
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What We Like

  • Hydrolyzed whey isolate for fast absorption
  • Simple macro profile with under 120 calories
  • Gluten-free and mixes with many liquids

Trade-offs

  • Only 20 servings per container
  • Contains 1g of sugar per serving

Dymatize ISO100 provides 25 grams of hydrolyzed whey isolate designed for rapid absorption, so it’s built for quick post-workout delivery when fast-digesting protein is the priority. The filtration process removes excess lactose, carbs, fat, and sugar, aligning with the brand’s description of pushing protein to the next level.

This formula delivers 25g of protein and 5g of BCAAs per serving, whereas the MuscleTech Nitro-Tech includes 3g of creatine. The mixability with various liquids offers versatility for shakes or recipes, suitable for different points in a fitness routine.

Best for: Athletes and gym-goers seeking a fast-absorbing, no-frills protein hit immediately after training. Not ideal for those looking for an all-in-one mass gainer or a protein source with added creatine.
#4Best Protein-Creatine Combo

MuscleTech Nitro-Tech Whey Protein Powder

MuscleTech Nitro-Tech Whey Protein Powder
Protein per serving30g
Creatine per serving3g
BCAAs per serving6.6g
Servings per tub40
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What We Like

  • Clinically studied formula for lean muscle gain
  • Combines whey protein and creatine in one scoop
  • Enhanced with digestive enzymes for absorption
  • Award-winning, patented 20-year formula

Trade-offs

  • Packaging may vary, which can confuse repeat buyers

The core fact here is 30 grams of protein and 3 grams of creatine in a single serving. That means you’re getting two foundational supplements for muscle growth and recovery without measuring out separate powders. This is the clear choice for someone who wants to streamline their post-workout routine into one efficient scoop. It’s backed by clinical research showing notable lean mass gains, which appeals to the skeptic who prefers data over marketing hype. The inclusion of a digestive enzyme complex is a thoughtful touch, aiming to make all that protein a bit easier on the stomach.

The tub stands a foot tall and weighs four pounds, a size that occupies noticeable space on a counter. Optimum Nutrition Gold Standard Whey Protein, for example, comes in a container that is over an inch shorter and two pounds lighter. The product’s fixed ratio means its creatine dose is tied to its protein serving, unlike taking separate supplements like Optimum Nutrition Creatine Monohydrate Powder. This integration suits a set protocol but limits independent adjustment of either component.

Best for: The lifter seeking a combined protein and creatine supplement to simplify their regimen.

Product photos

#5Best Clean Mass Gainer

Transparent Labs Mass Gainer Protein Powder

Transparent Labs Mass Gainer Protein Powder
Calories per serving770
Protein per serving53g grass-fed whey
Carbs per serving110g+ complex carbohydrates
Creatine per serving3g monohydrate
Artificial additivesNone
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What We Like

  • Includes a clinically dosed 3g of creatine monohydrate
  • Uses grass-fed whey and whole-food carbohydrate sources
  • Third-party tested with no artificial fillers or sweeteners
  • High-calorie formula designed for a clean caloric surplus

Trade-offs

  • High 110g+ carb load is excessive for non-bulking phases
  • 770-calorie serving size requires a significant appetite

A 770-calorie serving built from oat flour and sweet potato powder is designed for one job: pushing past a caloric plateau to gain lean mass. It suits someone who struggles to eat enough whole food and wants a cleaner alternative to typical maltodextrin-heavy gainers. The inclusion of 3g of creatine monohydrate and grass-fed whey rounds out a formula meant to support both muscle synthesis and workout performance directly in the shake.

Each serving delivers 770 calories from nutrient-dense sources like oat flour and sweet potato powder, which provides a substantial energy foundation for supporting a caloric surplus and lean mass goals. This high-calorie formula includes 110 grams of complex carbohydrates designed to fuel workouts and stabilize energy levels throughout the day. The product consolidates protein, carbohydrates, and creatine into a single supplement for convenience.

Best for: The hardgainer struggling to hit a clean caloric surplus for lean mass, not ideal for those maintaining weight or seeking pure protein isolation.
#6Best Gut-Friendly Protein

Animal Whey Isolate Protein Powder

Animal Whey Isolate Protein Powder
Protein per serving25 grams
Key protein sourceWhey protein isolate
Digestive supportAdded enzymes
BCAA content5.6 grams
ManufacturingMade in the USA
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What We Like

  • Includes digestive enzymes to reduce stomach discomfort
  • High 25g protein dose from fast-absorbing isolate
  • Manufactured in brand's own U.S. facilities for quality control
  • Contains a notable 5.6g of BCAAs per serving

Trade-offs

  • Four-pound container is large and may be cumbersome to store
  • Lacks the added creatine found in formulas like MuscleTech Nitro-Tech

The inclusion of digestive enzymes makes this protein powder a logical choice for anyone whose fitness routine is regularly sidelined by bloating or stomach upset. It delivers a solid 25 grams of protein from a whey isolate, which is absorbed quickly, and the brand’s control over its U.S. manufacturing means the label is reliable. This combination suits lifters who prioritize predictable digestion and straightforward muscle support over maximal calorie or creatine loading.

Animal Whey Isolate is a pure protein supplement focused on muscle recovery, not a mass gainer or a blend with additional ingredients like creatine. This makes its value about refinement for targeted post-workout nutrition rather than adding bulk or other compounds. For someone with a sensitive system seeking a clean protein, this straightforward design aligns with that need.

Best for: Lifters who need a high-quality protein that won't cause digestive distress. Not ideal for those seeking an all-in-one muscle builder with creatine or a high-calorie mass gainer.

Product photos

#7Best Pure Creatine

Muscle Feast Creapure Creatine Monohydrate

Muscle Feast Creapure Creatine Monohydrate
Creatine TypeCreapure Monohydrate
Purity99.9% Pure
Servings per container60 Servings
Serving size5000mg (5g)
Powder weight300g
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What We Like

  • Labdoor A+ quality ranking for purity
  • Keto-friendly and vegan formulation
  • No additives, only pure creatine
  • Compact 0.7 lb container for easy storage

Trade-offs

  • Slight settling requires thorough stirring before use
  • Unflavored powder may not appeal to all users

The 99.9% pure Creapure creatine monohydrate is about as close as you get to a pharmaceutical-grade muscle fuel. For the skeptical tinkerer who trusts a lab report over marketing copy, this is the point. It powers repeated high-intensity bursts and aids recovery with a single ingredient, which simplifies protocol testing and eliminates guesswork about filler reactions. This product suits anyone prioritizing traceable, third-party-verified purity above all else in their supplement stack.

The Muscle Feast Creapure tub holds 300 grams of pure creatine monohydrate, a compact size that stores easily in a gym bag or cabinet. Its 60 servings mean more frequent reorders are needed compared to larger containers listed for other brands. This supplement contains only pure creatine without added flavors or blends, so it serves as a foundational ingredient for someone mixing their own regimen.

Best for: A user seeking a pure, unflavored creatine monohydrate from a trusted source. Not ideal for someone seeking a flavored, all-in-one mass gainer or a multi-year bulk supply.

Product photos

#8Best Simple Ingredient Gainer

NAKED Chocolate Mass Gainer

NAKED Chocolate Mass Gainer
Protein per serving50g
Calories per serving1,360
Total carbohydrates251g
Key ingredientsWhey, casein, organic tapioca maltodextrin
Third-party certificationNSF Certified
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What We Like

  • Extremely simple, five-ingredient formula.
  • Uses organic tapioca maltodextrin, not wheat-based.
  • NSF certification verifies purity and safety.
  • Combines whey and casein for sustained protein synthesis.

Trade-offs

  • Serving size is very large at 1,360 calories.
  • Only 5g of sugar, but 251g total carbs per serving.

With only five ingredients listed, this mass gainer is for the tinkerer who wants to know exactly what they’re putting in their body. The combination of whey and casein provides a multi-phase protein release, which is a thoughtful touch for all-day muscle support. It’s a clean-bulk option, using organic coconut sugar and raw cacao instead of artificial sweeteners, making it a logical choice for someone prioritizing ingredient transparency over sheer convenience.

The trade-off is in the serving size itself. At 1,360 calories with 251 grams of carbs, this is a serious calorie vehicle. It’s designed for the dedicated hard gainer who needs that density, not someone looking for a light post-workout top-up. For a more moderate calorie boost with a focus on pure protein, you’d look at something like the Optimum Nutrition Gold Standard Whey, but that’s an entirely different tool for a different job.

Best for: The meticulous bulkers who prioritize ingredient purity and need a high-calorie, simple formula. Not ideal for those seeking a low-carb or light protein supplement.

Product photos

#9Best Budget Pick

Body Fortress Super Advanced Whey Protein

Body Fortress Super Advanced Whey Protein
Immune supportVitamins C, D & zinc
Container size1.78 pounds
GlutenNo gluten
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What We Like

  • Includes vitamins and zinc for immune support
  • No aspartame or gluten in the formula

Trade-offs

  • Serving size is two scoops for the 60g protein

The 60 grams of protein per serving is a substantial dose for rebuilding muscle, landing this squarely in the value-focused category of supplements. It’s a straightforward choice for someone prioritizing sheer protein quantity per scoop over premium processing or flavor complexity. The added zinc and vitamins are a pragmatic touch for anyone whose intense training schedule might otherwise leave them run down.

The trade-off is in the serving size and the package. You need two scoops to get that 60 grams, which means the 1.78-pound tub won’t last as long as the 4-pound jugs from brands like MuscleTech. It’s a classic budget-pick scenario: you get a lot of core protein for your money, but you’ll be reordering more often than with a bulk option. For a more concentrated protein with faster absorption, you’d look at a whey isolate like Dymatize ISO100.

Best for: Users seeking a whey protein with immune-supporting vitamins. Not ideal for those needing a large bulk container or a product specifically labeled as a fast-absorbing isolate.

Product photos

#10Best High-Serving Creatine

Nutrex Research Creatine Monohydrate Powder

Nutrex Research Creatine Monohydrate Powder
Creatine per serving5g
Creatine typeMicronized Monohydrate
Third-party testingYes
Manufacturing standardGMP-compliant
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What We Like

  • Exceptionally high 400-serving container size
  • Micronized powder for better mixability
  • Clinically dosed 5g formula with no proprietary blends
  • Third-party tested for purity and potency

Trade-offs

  • Large 4.4 lb container requires significant storage space
  • Unflavored powder demands mixing with another beverage

Nutrex Research Creatine Monohydrate Powder provides 5 grams of pure creatine per serving, a clinically studied dose for supporting strength and muscle growth. The micronized powder is designed for smooth mixing in liquids, which helps avoid the grittiness some users report with standard formulas. Its manufacturing in GMP-compliant facilities and third-party testing offer assurance of purity, a key consideration for athletes focused on clean supplementation.

The sheer physical size of the container is its main trade-off. At 4.4 pounds and 8 inches tall, it will dominate a supplement shelf. If you have limited space, prefer to switch flavors or brands frequently, or are new to creatine, a smaller option like the Muscle Feast Creapure might be a more practical starting point. This product is for the committed user who values bulk simplicity over cabinet flexibility.

Best for: Serious athletes and bodybuilders seeking a high-volume, no-frills creatine supply for consistent long-term use. Not ideal for those with minimal storage space or anyone wanting to sample different brands.

Product photos

How We Evaluated Supplements For Muscle Growth

Our evaluation relied on manufacturer specifications, scientific literature, and expert round-ups to identify supplements with proven, effective ingredients. We prioritized products with clinically dosed formulas, like 5g of creatine monohydrate or whey protein with a complete essential amino acid profile, because these are the building blocks for muscle repair and growth. We also considered quality markers such as third-party testing for banned substances and formulations designed for easy mixing and digestion.

Owner feedback helped confirm real-world factors like mixability, taste tolerance, and the practicality of serving sizes and container storage. This research-based approach identifies effective products, but it cannot replicate the individual results of personal use, which vary with diet, training, and physiology.

What To Look For In Supplements For Muscle Growth

Focus on supplements that directly support the biological processes of hypertrophy: stimulating muscle protein synthesis and providing energy for intense training. Your choice should align with your specific goal, whether it’s adding a foundational protein, maximizing strength with creatine, or hitting a calorie surplus for mass.

The most effective supplements for building muscle are those backed by extensive research, primarily high-quality protein and creatine monohydrate. Look for products with transparent ingredient lists, clinically effective dosages, and quality assurance from third-party testing.

Protein Type and Quality

Protein is the raw material for muscle repair and growth. Whey protein, particularly isolates and concentrates, is a top choice due to its rapid absorption and high leucine content, which triggers muscle protein synthesis. For a slower-digesting option that provides a sustained amino acid release, consider blends that include casein, often taken before sleep. The best protein supplements will clearly state their protein source and grams per serving, with many quality options offering 20-25g per scoop from whey or a blend.

Key Active Ingredients

Beyond protein, specific ingredients have strong scientific support. Creatine monohydrate at 3-5g daily is one of the most researched supplements for mass, reliably increasing strength and lean mass gains when combined with resistance training. Some formulas combine protein and creatine for convenience. For those focused on endurance during high-volume training, ingredients like beta-alanine can help buffer muscle fatigue. Always check that these active ingredients are included in clinically studied doses, not hidden in proprietary blends.

Your Specific Goal

Your supplement should match your current training phase. For a lean mass focus with precise calorie control, a pure whey isolate or creatine powder offers flexibility. If you’re in a dedicated mass gain phase, a high-calorie mass gainer with clean carbohydrate sources can help create the necessary surplus. For those prioritizing digestive comfort, look for proteins with added enzymes. A simple rule is to choose a product that solves your biggest bottleneck, whether that’s daily protein intake, workout performance, or caloric intake.

  • Determine if you need a pure protein, a pure creatine, or a combined formula.
  • Check the calorie and macronutrient profile to ensure it aligns with your daily targets.
  • Consider mixability and flavor if you’ll be consuming it daily; an unflavored powder offers more versatility.
  • Look for third-party testing seals (like NSF or Informed Choice) for quality and safety assurance.
  • Assess container size relative to your storage space and frequency of purchase.

Match the supplement’s primary function, be it protein delivery, creatine loading, or calorie addition, to your most immediate muscle-building need.

Supplements For Muscle Growth Compared

The table below provides a detailed comparison of the key features across all ten supplements to help you see the differences at a glance.

ProductProtein per servingCreatine per servingBCAAs per serving
Optimum Nutrition Creatine Monohydrate PowderN/A5gN/A
Optimum Nutrition Gold Standard Whey Protein24gN/A5.5g
Dymatize ISO100 Whey Isolate Protein Powder25gN/A5.5g
MuscleTech Nitro-Tech Whey Protein Powder30g3g6.6g
Transparent Labs Mass Gainer Protein Powder53g grass-fed whey3g monohydrateN/A
Animal Whey Isolate Protein Powder25 gramsN/A5.6 grams
Muscle Feast Creapure Creatine MonohydrateN/A5000mg (5g)N/A
NAKED Chocolate Mass Gainer50gN/A11.6g
Body Fortress Super Advanced Whey Protein60 gramsN/A12 grams
Nutrex Research Creatine Monohydrate PowderN/A5gN/A

Frequently Asked Questions

What’s the best supplement to gain muscle?

For most people seeking efficient muscle growth, the best starting point is a high-quality creatine monohydrate supplement, like our top pick, due to its extensive research backing for increasing strength and lean mass. Pairing creatine with a sufficient daily protein intake, from food or a supplement like whey protein, creates a powerful foundation for hypertrophy.

What is the best supplement for building muscle mass?

The most effective supplement for building muscle mass is creatine monohydrate, taken consistently at 5 grams daily. For adding size, a caloric surplus is also required, which can be supported by a clean mass gainer supplement if you struggle to eat enough whole food calories.

Can I still build muscle on metformin?

Building muscle while on metformin is absolutely possible, as the drug does not block muscle protein synthesis. Success hinges on maintaining a consistent resistance training program and ensuring adequate daily protein and calorie intake. Consulting with your healthcare provider about your fitness goals is always recommended.

What are the big 5 supplements?

In the context of muscle growth, the “big” evidence-based supplements often cited are creatine monohydrate, whey protein, branched-chain amino acids (BCAAs), beta-alanine, and potentially a mass gainer for those needing extra calories. However, BCAAs may be redundant if your total protein intake is already sufficient.

What is the best protein supplement for muscle growth?

The best protein supplement is one you’ll consistently use that fits your digestion and goals. Whey protein isolate, like our fast-absorbing pick, is excellent for post-workout due to its rapid absorption. A whey concentrate blend, like our premium pick, offers a versatile and cost-effective option for general daily protein needs.

The Bottom Line

Optimum Nutrition Creatine Monohydrate Powder is our best overall pick for its pure, effective, and well-researched formula, ideal for any lifter looking to boost strength and lean mass gains reliably. If your priority is a high-quality protein from a trusted brand, consider the premium Optimum Nutrition Gold Standard Whey Protein; for a straightforward, high-volume creatine supply, look to the Nutrex Research Creatine Monohydrate Powder.

Ultimately, the most important factor is consistency, both in your training and in taking a supplement that directly addresses a gap in your nutrition. A well-dosed creatine or protein product you take daily will far outperform a more complex supplement you use sporadically.