10 Best Over The Counter Progesterone Pills in 2026

A precise 20mg dose per pump makes this cream straightforward to meter, which is critical when tracking topical hormone application. The USP grade stamp signals a commitment to pharmaceutical-grade raw materials, a non-negotiable for anyone skeptical of supplement quality. Its scent-free, paraben-free formulation is built for sensitive skin, and the wild yam base offers a classic, natural progesterone pathway. This combination of metered dosing and clean, verified ingredients makes it a reliable baseline for anyone new to OTC progesterone support.

The trade-off is in the container size and concentration. At 3 ounces, it holds less product than many competitors, and the progesterone is not blended with the moisturizing botanical oils found in picks like Karuna Progesterone Plus. It’s a focused, no-frills formula. For someone who values simplicity and verified quality over a richer cream base, this is a logical starting point.

The Platt Wellness cream contains 50 milligrams of USP progesterone per gram, a concentration that allows a smaller physical volume to be applied. This suits someone who has established a need for a higher-potency topical formula. The fragrance-free cream comes from a government-registered facility and uses an airless pump for consistent dosing.

Its bottle is relatively tall, which might not fit neatly in every medicine cabinet. The product delivers a measured pump of cream, which offers less granular control than a drop-based system for someone still experimenting with dosage. For those who have dialed in their needs and want a straightforward, high-concentration topical, this is a no-fuss option.

Each drop delivers 4 mg of progesterone in a simple three-ingredient oil, which offers a minimalist approach to supplementation. This suits anyone wanting to avoid complex ingredient lists and synthetic additives, as it prioritizes purity and a known source for each component. The amber glass bottle and integrated glass pipette are thoughtful design choices that protect the oil from light and prevent plastic leaching. This makes it a good fit for the detail-oriented user who values material quality as much as the formula itself.

BioMatrix Progesterone Oil provides 4mg of progesterone per drop in a simple three-ingredient oil formula, which allows for precise, incremental dosing. In contrast, some creams like NOW Foods Natural Progesterone Cream deliver 20mg per pump. This difference in format means users must consider whether they prefer the controlled application of an oil dropper or the potentially faster coverage of a cream pump.

A 30mg dose of micronized progesterone per quarter-teaspoon puts it on the higher end for over-the-counter support, which matters if you’re following a specific milligram protocol. The addition of Black Cohosh and Chasteberry makes this a multi-herb formulation, suited for someone who wants a broader botanical approach to menopausal rhythm support, not just isolated progesterone. The skin-loving ingredients like jojoba and shea butter are a practical touch, turning a necessary application into a moisturizing routine.

A quarter teaspoon delivers 30mg of micronized progesterone from wild yam, providing a specific dosage that requires careful measurement. This cream format relies on manual dosing instead of the fixed dose of a pill, which introduces room for error. Compared to the NOW Foods cream, which delivers 20mg per pump, Karuna’s formulation includes additional herbs like Black Cohosh and Chasteberry for wellness support.

The product contains 2000mg of progesterone in a 4oz container, which means it’s formulated as a long-lasting topical cream rather than an oral pill. Its dermatologist-tested and hypoallergenic formula, free from common irritants, suits daily skin care for sensitive types, though it’s explicitly marketed for cosmetic use.

Emerita Progest Cream is formulated without parabens, a detail for shoppers who prioritize avoiding that specific class of preservatives. It comes from a brand concentrated in the women’s health category, and its small tube is designed for focused, personal use.

The product does not specify a progesterone amount per application, unlike alternatives such as NOW Foods Natural Progesterone Cream which lists 20mg per pump. This means users managing a precise dosage protocol would need to look elsewhere for that level of measurement detail.

BAVQEZA Progesterone Cream comes in a 4-ounce bottle with approximately 120 pumps, offering a larger supply than many other creams in its category. This volume means fewer purchases over time for regular users. The unscented, hypoallergenic formula with aloe, jojoba, and sunflower seed oil is designed to moisturize and condition the skin, providing a comfortable base.

This cream does not list its progesterone potency, as it is sold as a cosmetic product rather than a dosed supplement. That differs from products like NOW Foods Natural Progesterone Cream, which specifies 20mg per pump. The BAVQEZA cream’s value lies in its bulk and skin feel, but verifying its hormonal activity would require third-party testing it doesn’t provide.

A 2 oz cream formulated specifically for pre-menopause and PMS symptoms means you’re getting a product aimed at the cyclical hormonal changes preceding full menopause, not just general support. It suits someone seeking a natural, paraben-free option from a brand with decades of experience, who prefers the flexibility of applying it to various skin areas like the chest or neck as needed. The lack of a stated progesterone percentage, however, requires you to trust the brand’s professional formulation over a measurable dose.

Unlike products that specify a milligram amount per dose, Progonol Cream keeps its potency undisclosed. This makes it a simpler, more intuitive pick for symptom management if you don’t want to calculate milligrams, but a less transparent one if you’re comparing strengths directly. It’s a straightforward choice for applying a trusted formula broadly, rather than a precision tool for targeted dosing.

A 7.5% progesterone concentration in a pharmacist-formulated cream signals a serious, professionally considered product. It’s for the person who prioritizes a clean, bioidentical formula from a trusted source over a purely cosmetic application. The inclusion of hyaluronic acid and plant-based moisturizers suggests a dual focus on hormonal support and skin health, appealing if you want your topical progesterone to also act as a quality moisturizer without synthetic additives.

Designed by pharmacists and trusted by dermatologists, HelloPharmacist BioIdentical Cream offers a professional-grade foundation for daily hormonal and skin wellness. Its formula is enriched with hyaluronic acid and plant-based moisturizers for a soothing application, and it explicitly avoids synthetic fragrances, parabens, and GMOs. For buyers comparing options, other products like BioMatrix Progesterone Oil quantify progesterone per drop, while this cream focuses on a clean, wild yam-derived formula in a compact 5-inch tube.

A three-drop serving delivers exactly 3 mg of progesterone, suspended in MCT oil with a bit of vitamin E. This makes Svasthya’s liquid the standout for anyone who needs to micro-adjust their intake or prefers to start with a very small, measurable amount. The formula uses only three ingredients: progesterone, vitamin E, and MCT oil.

Using this product requires a dropper bottle instead of a pump-top cream. You’ll need a steady hand and a moment of focus for each dose, which isn’t as convenient as the single-handed operation of a pump dispenser.